127986-91-8Relevant academic research and scientific papers
Method for synthesizing chiral deuterated primary alcohol
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Paragraph 0031-0036; 0079-0083, (2021/05/29)
The invention discloses a method for synthesizing chiral deuterated primary alcohol. The method comprises the following step: reacting an aldehyde compound in an aprotic organic solvent at room temperature under the action of a chiral cobalt catalyst by t
Asymmetric transfer hydrogenation of benzaldehydes
Yamada, Issaku,Noyori, Ryoji
, p. 3425 - 3427 (2007/10/03)
(Equation Presented) A combined system of RuCl[(R,R)-YCH(C6H5)CH(C6H5)NH 2](η6-arene) (Y = NSO2C6H4-4-CH3 or O) and t-C4H9OK catalyzes the asymmetric transfer hydrogenation of various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in 95-99% ee and with >99% isotopic purity. Reaction of benzaldehydes with a DCO2D-triethylamine mixture and the R,R catalyst affords the S deuterated alcohols in 97-99% ee.
A NEW CHIRAL CATALYST FOR THE ENANTIOSELECTIVE SYNTHESIS OF SECONDARY ALCOHOLS AND DEUTERATED PRIMARY ALCOHOLS BY CARBONYL REDUCTION
Corey, E. J.,Link, John O.
, p. 6275 - 6278 (2007/10/02)
An efficient synthesis of (S)-(-)-2-(di-β-naphthylhydroxymethyl)pyrrolidine (1) makes available the oxazaborolidine derivates 2 and 3 which are excellent catalysts for borane reduction of a variety of achiral ketones to chiral secondary alcohols, e.g. acetophenone, 98percent ee; α-tetralone, 95percent ee; and methyl-4-oxo-4-phenyl butyrate, 96percent ee.The synthesis of chiral 1-deuterio primary alcohols from achiral aldehydes with B-n-butyloxazaborolidine (4) as catalyst in the presence of 2H-catecholborane as reductant has also been demonstrated, e.g. benzaldehyde, 95percent ee; cyclohexanecarboxaldehyde, 92percent ee; and n-octanal, 90percent ee.
