127997-06-2

Usage

Uses

Used in Pharmaceutical Industry:
tert-butyl (4R)-4-(R)-hydroxy[(2S)-5-oxo-2,5-dihydrofuran-2-yl]methyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate is used as a potential pharmaceutical compound for its unique structure and functional groups, which may offer new avenues for drug development and therapeutic applications.
Used in Organic Synthesis:
tert-butyl (4R)-4-(R)-hydroxy[(2S)-5-oxo-2,5-dihydrofuran-2-yl]methyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate is used as a building block or intermediate in the synthesis of more complex organic molecules, leveraging its functional groups and stereochemistry for the creation of novel compounds.
Used in Materials Science:
tert-butyl (4R)-4-(R)-hydroxy[(2S)-5-oxo-2,5-dihydrofuran-2-yl]methyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate is used as a component in the development of new materials, such as polymers or coatings, where its unique structure and properties can contribute to enhanced performance or novel functionalities.

Upstream product

• 61550-02-5 (furan-2-yloxy)-trimethylsilane 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 

Downstream Products

• 136489-92-4 (S)-tert-Butoxycarbonylamino-((2R,3R,4R,5R,6S)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl)-acetic acid methyl ester 
• 135086-50-9 (R)-2,2-Dimethyl-4-[(R)-((2R,3R,4R)-5-oxo-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl)-trimethylsilanyloxy-methyl]-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

THE FOUR-CARBON ELONGATION OF THREE-CARBON CHIRAL SYNTHONS USING 2-(TRIMETHYLSILOXY)FURAN: HIGHLY STEREOCONTROLLED ENTRY TO ENANTIOMERICALLY PURE SEVEN-CARBON α,β-UNSATURATED 2,3-DIDEOXYALDONOLACTONES

The BF3-promoted addition of 2-(trimethylsiloxy)furan to three carbon synthons derived from D- and L-glyceraldehyde, D- and L-serinal, and imines thereof furnishes C7 α,β-unsaturated 2,3-dideoxy-aldonolactone derivatives in high yield, with very high level of diastereoselection.In all the cases, compounds having 4,5-threo:5,6-erythro relative stereodisposition preferentially emerge from the reactions, accompanied by only marginal amounts of 4,5-erythro:5,6-threo epimers.An empirical rule for the rapid assignment of the configuration at C-4 (γ-carbon) of γ-substituted unsaturated and saturated β-butyrolactones is given, based upon the sign of the optical rotation values.

SYNTHESIS OF ENANTIOMERICALLY PURE 2,3-DIDEOXY-HEPT-2-ENONO-1,4-LACTONE DERIVATIVES VIA DIASTEREOSELECTIVE ADDITION OF 2-(TRIMETHYLSILOXY)FURAN TO D-GLYCERALDEHYDE AND D-SERINAL-BASED THREE-CARBON SYNTHONS

The BF3-promoted addition of 2-(trimethylsiloxy)furan to 2,3-O-isopropylidene-D-glyceraldehyde and N-t-BOC-D-serinal, and the corresponding imine derivatives gives the title seven-carbon lactones with great preference for the D-arabino diastereoisomers.