128-57-4

Basic information

• Product Name: Sennoside B
• Synonyms: (9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic acid;(9S,9'R)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic acid;(9S)-9-[(9R)-2-carboxy-4-hydroxy-10-keto-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-keto-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-9H-anthracene-2-carboxylic acid;Sennoside B ,98%;Sennoside B (20 mg);Tisasen B;(9R,9'S)-4,4'-dihydroxy-10,10'-dioxo-5,5'-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)-9,9',10,10'-tetrahydro-[9,9'-bianthracene]-2,2'-dicarboxylic acid;Sennoside B, froM FoliuM sennae
• CAS NO: 128-57-4
• Molecular Formula: C₄₂H₃₈O₂₀
• Molecular Weight: 862.74
• EINECS: 204-895-0
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Anthraquinones, Hydroquinones and Quinones;The group of Sennosides
• Mol File: 128-57-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 209～212℃
• Boiling Point: 698.48°C (rough estimate)
• Flash Point: 348.6 °C
• Appearance: light yellow crystal
• Density: 1.3066 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7630 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Very Slightly, Heated), Methanol (Slightly, Heated)
• PKA: 3.31±0.40(Predicted)
• Stability: Hygroscopic
• BRN: 5723747
• CAS DataBase Reference: Sennoside B(CAS DataBase Reference)
• NIST Chemistry Reference: Sennoside B(128-57-4)
• EPA Substance Registry System: Sennoside B(128-57-4)

Safety Data

• Statements: 22
• Safety Statements: 22-45-24/25
• WGK Germany: 3
• Hazardous Substances Data: 128-57-4(Hazardous Substances Data)

Usage

Chemical Properties

White to brown powder

Uses

Sennoside B is used in the inhibition of platelet driven growth factor (PDGF) used and may inhibit proliferative disease which depend upon the PDGF pathway. Laxative.

Definition

ChEBI: A member of the class of sennosides that is (9R,9'S)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'.

Purification Methods

Sennoside B forms yellow crystals from aqueous acetone or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3402.]

InChI:InChI=1/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1

Downstream Products

• 480-09-1 rhein anthrone 
• 517-44-2 (+)-4,5,4',5'-tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarboxylic acid 
• 517-44-2 sennidin B 
• 82334-26-7 sennidin-B-8-monoglucoside 
• 82334-26-7 sennidin-B-8'-monoglucoside 
• 517-44-2 sennidin A 
• 82334-26-7 sennidin A-8-monoglucoside 

Related news

Sennoside B (cas 128-57-4) inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells09/29/2019

To address the possibility that sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling.Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of sennoside B. Activation of the PDGF signaling pathway ...detailed

Simple and rapid analysis of sennoside A and Sennoside B (cas 128-57-4) contained in crude drugs and crude drug products by solid-phase extraction and high-performance liquid chromatography09/25/2019

The sennoside A (SA) and sennoside B (SB) contents of various samples of crude drugs were determined using solid-phase extraction (SPE) and HPLC. The samples examined were crude drugs (senna leaf, senna pods, and rhubarb), conventional crude drug products, and Kampo formulations. The sample solu...detailed