Welcome to LookChem.com Sign In|Join Free

CAS

  • or

128007-31-8

Post Buying Request

128007-31-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • Arvanil,N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide

    Cas No: 128007-31-8

  • No Data

  • No Data

  • No Data

  • NovaChemistry
  • Contact Supplier

128007-31-8 Usage

Uses

Arvanil is a cannabinoid CB1?and vanilloid TRPV1 (VR) agonist.

Biological Activity

Cannabinoid CB 1 and vanilloid TRPV1 (VR1) agonist (K i values are 0.5 and 0.3 μ M respectively). Also inhibits the anandamide transporter (IC 50 = 3.6 μ M). Analgesic, vasodilatory and anti-inflammatory in vivo .

Biochem/physiol Actions

Arvanil is an activator of cannabinoid and vanilloid receptors, and a potent inhibitor of anandamide accumulation. Arvanil inhibits growth of astrocytoma xenograft tumors in mice, mimicing the effect of neural precursor cells, that have been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids.

Check Digit Verification of cas no

The CAS Registry Mumber 128007-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,0,0 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 128007-31:
(8*1)+(7*2)+(6*8)+(5*0)+(4*0)+(3*7)+(2*3)+(1*1)=98
98 % 10 = 8
So 128007-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C28H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-28(31)29-24-25-21-22-26(30)27(23-25)32-2/h7-8,10-11,13-14,16-17,21-23,30H,3-6,9,12,15,18-20,24H2,1-2H3,(H,29,31)/b8-7-,11-10-,14-13-,17-16-

128007-31-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma

  • (SML0520)  Arvanil  ≥98% (HPLC), solution (in ethanol)

  • 128007-31-8

  • SML0520-5MG

  • 761.67CNY

  • Detail
  • Sigma

  • (SML0520)  Arvanil  ≥98% (HPLC), solution (in ethanol)

  • 128007-31-8

  • SML0520-25MG

  • 2,439.45CNY

  • Detail

128007-31-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Arvanil,N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide

1.2 Other means of identification

Product number -
Other names Picrotoxin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128007-31-8 SDS

128007-31-8Downstream Products

128007-31-8Related news

Effect of ARVANIL (cas 128007-31-8) (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide–capsaicin hybrid, on ion currents in NG108-15 neuronal cells08/27/2019

The effects of arvanil (N-arachidonoyl-vanillyl-amine), a structural hybrid between capsaicin and anandamide, on ion currents in a mouse neuroblastoma and rat glioma hybrid cell line, NG108-15, were examined with the aid of the whole-cell voltage-clamp technique. Arvanil (0.2–50 μM) caused an ...detailed

ARVANIL (cas 128007-31-8) and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells08/26/2019

In this study we analysed the regulation of gene expression by arvanil and anandamide in human peripheral blood mononuclear cells (PBMCs) to clarify their immunosuppressive properties. PBMCs were activated, leading to CD36 down regulation, that was normalized by arvanil and anandamide. We used m...detailed

ARVANIL (cas 128007-31-8) inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis08/24/2019

This study examined the immunomodulatory effect of arvanil, a synthetic capsaicin–anandamide hybrid. Arvanil inhibits lymphocyte proliferation and IFN-γ production. The phenotype of activated CD4 + T cells treated with arvanil shows a down-regulation of T cell activation markers such as CD25, ...detailed

Pulmonary, Gastrointestinal and Urogenital PharmacologyMidcervical vagotomy precludes respiratory response to novel anti-inflammatory and anti-tumour drug ARVANIL (cas 128007-31-8) in rats08/22/2019

Arvanil is a metabolically stable hybrid between anandamide and capsaicin. The present study was designed to test the role of the vagal pathway in post-arvanil respiratory and blood pressure responses. Respiratory and pressure changes evoked by an intravenous injection of arvanil were investigat...detailed

128007-31-8Relevant articles and documents

The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway

Sancho, Rocio,De La Vega, Laureano,Appendino, Giovanni,Di Marzo, Vincenzo,Macho, Antonio,Munoz, Eduardo

, p. 1035 - 1044 (2003)

1. Arvanil (N-arachidonoylvanillamine), a nonpungent capsaicin-anandamide hybrid molecule, has been shown to exert biological activities through VR1/CB1-dependent and -independent pathways. We have found that arvanil induces dose-dependent apoptosis in the lymphoid Jurkat T-cell line, but not in peripheral blood T lymphocytes. Apoptosis was assessed by DNA fragmentation through cell cycle and TUNEL analyses. 2. Arvanil-induced apoptosis was initiated independently of any specific phase of the cell cycle, and it was inhibited by specific caspase-8 and -3 inhibitors and by the activation of protein kinase C. In addition, kinetic analysis by Western blots and fluorimetry showed that arvanil rapidly activates caspase-8, -7 and -3, and induces PARP cleavage. 3. The arvanil-mediated apoptotic response was greatly inhibited in the Jurkat-FADDDN cell line, which constitutively expresses a negative dominant form of the adapter molecule Fas-associated death domain (FADD). This cell line does not undergo apoptosis in response to Fas (CD95) stimulation. 4. Using a cytofluorimetric approach, we have found that arvanil induced the production of reactive oxygen species (ROS) in both Jurkat-FADD+ and Jurkat-FADDDN cell lines. However, ROS accumulation only plays a residual role in arvanil-induced apoptosis. 5. These results demonstrate that arvanil-induced apoptosis is essentially mediated through a mechanism that is typical of type II cells, and implicates the death-inducing signalling complex and the activation of caspase-8. This arvanil-apoptotic activity is TRPV1 and CB-independent, and can be of importance for the development of potential anti-inflammatory and antitumoral drugs.

Vanilloids. 1. Analogs of Capsaicin with Antinociceptive and Antiinflammatory Activity

Janusz, John M.,Buckwalter, Brian L.,Young, Patricia A.,LaHann, Thomas R.,Farmer, Ralph W.,et al.

, p. 2595 - 2604 (2007/10/02)

As part of a program to establish structure-activity relationships for vanilloids, analogs of the pungent principle capsaicin, the alkyl chain portion the parent structure (and related compounds derived from homovanillic acid) was varied.In antinociceptive and antiinflammatory assays (rat and mouse hot plate and croton oil-inflamed mouse ear), compounds with widely varying alkyl chain structures were active.Short-chain compounds were active by systemic administration in the assays mentioned above but they retained the high pungency and acute toxicity characteristic of capsaicin.In contrast, the long chain cis-unsaturates, NE-19550 (vanillyloleamide) and NE-28345 (oleylhomovanillamide), were orally active, less pungent, and less acutely toxic than capsaicin.The potential of these compounds as antiinflammatory/analgesic agents is discussed in light of recent data on the mechanism of action of vanilloids on sensory nerve fibers.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 128007-31-8