1280126-64-8Relevant academic research and scientific papers
Inherent oxygen preference in enolate monofluoromethylation and a synthetic entry to monofluoromethyl ethers
Nomura, Yoshinori,Tokunaga, Etsuko,Shibata, Norio
supporting information; experimental part, p. 1885 - 1889 (2011/04/22)
Expect the unexpected: The self-stable salts 1, X=OTf, PF6, x=2, y=1, developed for electrophilic monofluoromethylation showed inherent selectivity for the O-alkylation of enolates, thus providing access to monofluoromethyl ethers, which are difficult to obtain by the direct electrophilic fluoromethylation of alcohols. Salt 1, X=BF4, x=0, y=3, in contrast leads to C-alkylated products.
