128013-65-0Relevant articles and documents
A convenient synthesis of 3-alkyl-4-aminobutanoic acids
Andruszkiewicz,Silverman
, p. 953 - 955 (1989)
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Preparation method of pregabalin intermediate ethyl 3-nitromethyl-5-methylhexanoate
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Paragraph 0035; 0038; 0040; 0042; 0044-0046; 0048; 0050, (2019/01/08)
The invention discloses a preparation method of a pregabalin intermediate ethyl 3-nitromethyl-5-methylhexanoate. The method comprises the steps: reacting raw materials, namely ethyl 5-methyl-2-hexenoate as shown in a formula I and nitromethane in an appropriate organic solvent A at 20-150 DEG C under the action of a supported organic catalyst by taking nitromethane as a nucleophilic reagent to prepare ethyl 3-nitromethyl-5-methylhexanoate as shown in a formula II, wherein the organic solvent A is one selected from the followings: acetonitrile, methanol, ethyl acetate, dichloromethane, ethanol,toluene and 1,4-dioxane. Ethyl 3-nitromethyl-5-methylhexanoate is prepared by using the supported organic catalyst low in cost, easy to prepare and environment-friendly and is high in reaction yieldand product purity.
PROCESS FOR PREPARING PREGABALIN
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, (2011/02/24)
The invention relates to a process for preparing a compound of formula (I): wherein said process comprises hydrogenation of a compound of formula (II): under alkaline conditions, wherein R represents hydrogen or a labile group capable of being converted to hydrogen. The invention also relates to intermediates used in said process, to the use of said intermediates in the preparation of pregabalin and to a process for resolving racemic compounds of formula (I).