1280185-91-2Relevant academic research and scientific papers
Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction
Gordon, Christopher P.,Young, Kelly A.,Hizartzidis, Lacey,Deane, Fiona M.,McCluskey, Adam
, p. 1419 - 1428 (2011)
Rapid access to the quinolin-2-(1H)-one scaffold is afforded by a sequential 4 component Ugi-Knoevenagel condensation of an aminophenylketone, an aromatic aldehyde possessing electron donating moieties, cyanoacetic acid and an aliphatic isocyanide, in mod
Discovery of acrylonitrile-based small molecules active against Haemonchus contortus
Gordon, Christopher P.,Hizartzidis, Lacey,Tarleton, Mark,Sakoff, Jennette A.,Gilbert, Jayne,Campbell, Bronwyn E.,Gasser, Robin B.,McCluskey, Adam
supporting information, p. 159 - 164 (2014/03/21)
We report the discovery of a series of acrylonitrile-containing molecules and α-amino amides which cause 99-100% lethality in H. contortus. Of the 22 acrylonitrile analogues investigated, the most active were 2-cyano-3-[1-(3-dimethylaminopropyl)-2-methyl-
