1280185-93-4Relevant academic research and scientific papers
Quinolone-1-(2: H)-ones as hedgehog signalling pathway inhibitors
Trinh, Trieu N.,McLaughlin, Eileen A.,Abdel-Hamid, Mohammed K.,Gordon, Christopher P.,Bernstein, Ilana R.,Pye, Victoria,Cossar, Peter,Sakoff, Jennette A.,McCluskey, Adam
supporting information, p. 6304 - 6315 (2016/07/11)
A series of quinolone-2-(1H)-ones derived from the Ugi-Knoevenagel three- and four-component reaction were prepared exhibiting low micromolar cytotoxicity against a panel of eight human cancer cell lines known to possess the Hedgehog Signalling Pathway (H
Discovery of acrylonitrile-based small molecules active against Haemonchus contortus
Gordon, Christopher P.,Hizartzidis, Lacey,Tarleton, Mark,Sakoff, Jennette A.,Gilbert, Jayne,Campbell, Bronwyn E.,Gasser, Robin B.,McCluskey, Adam
supporting information, p. 159 - 164 (2014/03/21)
We report the discovery of a series of acrylonitrile-containing molecules and α-amino amides which cause 99-100% lethality in H. contortus. Of the 22 acrylonitrile analogues investigated, the most active were 2-cyano-3-[1-(3-dimethylaminopropyl)-2-methyl-
Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction
Gordon, Christopher P.,Young, Kelly A.,Hizartzidis, Lacey,Deane, Fiona M.,McCluskey, Adam
experimental part, p. 1419 - 1428 (2011/04/21)
Rapid access to the quinolin-2-(1H)-one scaffold is afforded by a sequential 4 component Ugi-Knoevenagel condensation of an aminophenylketone, an aromatic aldehyde possessing electron donating moieties, cyanoacetic acid and an aliphatic isocyanide, in mod
