1280210-79-8

Basic information

• Product Name: 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
• Synonyms: 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester;tert-butyl 4,6-dihy dropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate;Pyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid, 2,6-dihydro-, 1,1-dimethylethyl ester;tert-butyl pyrrolo[3,4-c]pyrazole-5(2H,4H,6H)-carboxylate;tert-butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate;2,6-Dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid 1,1-dimethylethyl ester;Omarigliptin Impurity 9
• CAS NO: 1280210-79-8
• Molecular Formula: C₁₀H₁₅N₃O₂
• Molecular Weight: 209.245
• EINECS: 1592732-453-0
• Mol File: 1280210-79-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 366.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.52±0.20(Predicted)
• CAS DataBase Reference: 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester(1280210-79-8)
• EPA Substance Registry System: 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester(1280210-79-8)

Safety Data

• Hazardous Substances Data: 1280210-79-8(Hazardous Substances Data)

Usage

General Description

2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester is a chemical compound belonging to the category of Pyrrolotriazolopyrazines, which are bioactive molecules. Its molecular formula is C14H18N4O2 signifying it consists of 14 carbon, 18 hydrogen, four nitrogen, and two oxygen atoms. This chemical is often used as an intermediate in various pharmaceutical syntheses. The hazardous properties and safety information about this chemical are not widely known, highlighting the importance of handling it with care when used in a laboratory or industrial setting. However, it is important to have complete information before using any chemical compound.

Upstream product

• 146256-98-6 4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 175463-32-8 3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 157327-42-9 3-(dimethylaminomethylene)-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 905274-02-4 tert-butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1226781-82-3 tert-butyl 2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate 
• 1270029-90-7 tert-butyl 2-(2-amino-2-oxoethyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate 
• 6573-19-9 1,4,5,6-tetrahydropyrrolo[3, 4-c]pyrazole 
• 1280210-80-1 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-ium benzenesulfonate 
• 1416137-42-2 C₁₇H₂₀FN₃O₄S 
• 1416137-41-1 C₂₁H₂₇FN₄O₄S 
• 1416137-43-3 C₂₃H₂₇FN₆O₂S 
• 1422466-75-8 C₁₂H₁₂FN₃O₂S 
• 1280210-99-2 tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(1,3-oxazol-4-ylmethyl)piperidin-3-yl}carbamate 
• 1280208-74-3 (2S)-1-{(2R,3S,5R)-3-amino-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-1-yl}propan-2-ol 
• 1280211-00-8 tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-[(2S)-2-hydroxypropyl]-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate 
• 1280208-75-4 (2S)-1-[(2R,3S,5R)-3-amino-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl]propan-2-ol 
• 1280211-05-3 tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate 
• 1280211-06-4 tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt) 

Relevant articles and documents

Pyrrolopyrazole derivatives and preparation method thereof, and application of pyrrolopyrazole derivatives in medicines

The invention relates to pyrrolopyrazole derivatives and a preparation method thereof, and application of the pyrrolopyrazole derivatives in medicines. Specifically, the invention relates to novel pyrrolopyrazole derivatives as shown in a general formula (I) in the specification, the preparation method of the pyrrolopyrazole derivatives and application of the pyrrolopyrazole derivatives or pharmaceutical compositions containing the pyrrolopyrazole derivatives as therapeutic agents, particularly as gastric acid secretion inhibitors and potassium ion competitive acid blockers P-CABs) in biological medicines. All the substituents (R1, R2, R3 and R4) and groups (X and Y) in the general formula (I) are as defined in the specification.

Pyrrolopyrazole derivatives and preparation method thereof, and application of pyrrolopyrazole derivatives in medicines

The invention relates to pyrrolopyrazole derivatives and a preparation method thereof, and application of the pyrrolopyrazole derivatives in medicines. Specifically, the invention relates to novel pyrrolopyrazole derivatives as shown in a general formula (I) in the specification, the preparation method of the pyrrolopyrazole derivatives and application of the pyrrolopyrazole derivatives or pharmaceutical compositions containing the pyrrolopyrazole derivatives as therapeutic agents, particularly as gastric acid secretion inhibitors and potassium ion competitive acid blockers P-CABs) in biological medicines. All the substituents (R1, R2, R3, R4 and R5) and a group (X) in the general formula (I) are as defined in the specification.

Preparation method for omarigliptin midbody

The invention provides an efficient and simple preparation method for omarigliptin midbody pyrrole and [3,4-c] pyrazol-5(2H,4H,6H)-carboxylic acid tert-butyl ester, wherein the total recovery ratio is close to 50%. The preparation method is easy to operate, the recovery ratio is higher, three produced wastes are less, and the method is suitable for industrialized production.