128039-26-9

Upstream product

• 101-84-8 diphenylether 
• 34883-46-0 1-(2-iodophenoxy)benzene 
• 48121-13-7 copper(I) 4-methoxyphenylacetylenide 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 144836-64-6 5-(p-methoxyphenyl)-6-(phenylthio)dibenzoxepine 
• 144836-65-7 5-iodo-6-(p-methoxyphenyl)dibenzoxepine 
• 144836-66-8 5-bromo-6-(p-methoxyphenyl)dibenzoxepine 
• 144836-67-9 E/Z-1,2-dibromo-1-(p-methoxyphenyl)-2-(o-phenoxyphenyl)ethene 
• 128039-27-0 5-(p-methoxyphenyl)benzoxepine 

Relevant academic research and scientific papers

Hypervalent iodine compound containing heterocyclic ring as well as preparation method and application thereof

The invention discloses a hypervalent iodine compound containing a heterocyclic ring as well as a preparation method and application thereof. A structure of the compound is shown as a formula (I): theformula (I) is shown in the description, wherein R is selected from hydrogen, halogen, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, nitryl, cyano, hydroxyl or -COOR'; R' is alkyl or halogenated alkyl; and Het is substituted or non-substituted 1,4-benzopyranone, substituted or non-substituted quinolone, substituted or non-substituted isoquinoline, substituted or non-substituted thiobenzopyranone, substituted or non-substituted coumarin and substituted or non-substituted oxepin. The compound disclosed by the invention is novel in structure and is the hypervalent iodine compound containing the heterocyclic ring; the hypervalent iodine compound is stable in structure and simple in preparation method; and meanwhile, the hypervalent iodine compound has a very good inhibition effect onML-1 and MOLM-13 cells and has an extremely great application prospect on prevention and/or treatment effect on leukemia.

Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source

A diverse set of novel heterocyclic iodoniums was synthesized for the first time. The reactions of these unique iodoniums with environmentally benign water as the oxygen source provided structurally complex oxygen-incorporated heteropolycycles that are essential motifs in natural products and biologically active compounds. The transformation only required low-cost copper acetate. Further derivatization of the obtained polycycles expanded the structural diversity, which is important in the building of chemical libraries for drug discovery.

Electrophile-induced Intramolecular Cyclization of ortho-(Aryloxy)phenylalkynes to Dibenzoxepines

Reaction of o-(aryloxy)phenylalkynes with electrophiles such as perchloric acid, tetrafluoroboric acid, benzenesulfenyl chloride, and iodine monochloride yielded dibenzoxepine derivatives.Cyclization to the dibenzoxepines competed with 1,2-addit