1280478-83-2Relevant academic research and scientific papers
Identification of a new series of non-peptidic NK3 receptor antagonists
Juhl, Karsten,Hansen, Tore,Kehler, Jan,Khanzhin, Nikolay A.,N?rgaard, Morten B.,Ruhland, Thomas,Larsen, Dorrit B.,Jensen, Klaus G.,Steiniger-Brach, Bj?rn,Nielsen, S?ren M.,Simonsen, Klaus B.
, p. 1498 - 1501 (2011/04/16)
The identification and structure-activity relationships of 2-aminomethyl-1-aryl cyclopropane carboxamides as novel NK3 receptor antagonists are reported. The compound series was optimized to give analogues with low nanomolar binding to the NK3 receptor and brain exposure, leading to activity in vivo in the senktide-induced hypoactivity model in gerbils.
CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS
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Page/Page column 58, (2010/02/10)
The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders.
