128050-92-0 Usage
General Description
(-)-Ci-cdp1 is a chemical compound that is a potent and selective inhibitor of the protein phosphatase 1 (PP1) enzyme. It exhibits high affinity and specificity for PP1, and is able to inhibit its activity in the low nanomolar range. This makes (-)-Ci-cdp1 a valuable tool for studying the physiological functions and signaling pathways regulated by PP1. Additionally, due to its selectivity, (-)-Ci-cdp1 has the potential to be used as a therapeutic agent for the treatment of diseases and disorders that are associated with dysregulation of PP1 activity, such as cancer, neurodegenerative diseases, and metabolic disorders. Overall, (-)-Ci-cdp1 represents a promising compound for both research and therapeutic applications targeting PP1.
Check Digit Verification of cas no
The CAS Registry Mumber 128050-92-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,0,5 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 128050-92:
(8*1)+(7*2)+(6*8)+(5*0)+(4*5)+(3*0)+(2*9)+(1*2)=110
110 % 10 = 0
So 128050-92-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H18N4O3/c22-20(28)24-6-4-13-14-8-16(23-15(14)1-2-17(13)24)19(27)25-10-11-9-21(11)5-3-12(26)7-18(21)25/h1-3,5,7-8,11,23H,4,6,9-10H2,(H2,22,28)
128050-92-0Relevant articles and documents
Synthesis of N-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI 1, and CI-CDPI 2: CC-1065 functional analogues incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit
Boger, Dale L.,Wysocki Jr., Ronald J.,Ishizaki, Takayoshi
, p. 5230 - 5240 (2007/10/02)
Full details of the synthesis of N-(phenylsulfonyl)- and N-((tert-butyloxy)carbonyl)-1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one [N-(phenylsulfonyl)-CI (9) and N-BOC-CI (10)] constituting stable derivatives of the parent cyclopropylcyclohexadienone rin