1280591-41-4Relevant academic research and scientific papers
An efficient diphosphine/hybrid-amine combination for ruthenium(II)- catalyzed asymmetric hydrogenation of aryl ketones
Li, Yuehui,Zhou, Yougui,Shi, Qixun,Ding, Kuiling,Noyori, Ryoji,Sandoval, Christian A.
scheme or table, p. 495 - 500 (2011/04/16)
Readily available and modular hybrid amine/benzimidazole-based 1H-benzimidazole-2-methanamine (BIMA) ligands in combination with 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (DIOP) afford efficient catalytic systems for the ruthenium(II)-catalyzed asymmetric hydrogenation (AH) of a number of aryl ketones. The AH proceeds smoothly with substrate-to-catalyst (S/C) molar ratios of up to 100,000 (TOF of 6500ah -1, 8aatm) giving chiral alcohols in up to 99% ee.
