1280677-71-5Relevant academic research and scientific papers
Cu(I)-Catalyzed domino reactions: Efficient and selective synthesis of 4h-chromenes and naphthalenes
Malakar, Chandi C.,Schmidt, Dietmar,Conrad, Juergen,Beifuss, Uwe
, p. 1972 - 1975 (2011)
Depending on the ratio of the substrates and the reaction conditions, the Cu(I)-catalyzed domino reaction between bromobenzyl bromides and β-ketoesters exclusively yields either 4H-chromenes or naphthalenes.
Assembly of 4H-chromenes, imidazobenzothiazines and quinazolines via copper-catalyzed domino reactions using 2-halobenzyl tosylates as substrates
Omar, Mohamed A.,Conrad, Jürgen,Beifuss, Uwe
, p. 5682 - 5695 (2015/03/30)
The use of 2-halobenzyl tosylates as substrates in copper-catalyzed domino intermolecular substitution/intramolecular arylation processes for the efficient and selective preparation of heterocycles is reported for the first time. Reaction of 2-halobenzyl tosylates with β-ketoesters delivers 4H-chromenes with yields ranging between 59 and 89%. Imidazobenzothiazines are formed with yields up to 82% upon reaction of 2-halobenzyl tosylates with 2-mercaptoimidazoles. When 2-halobenzyl tosylates are reacted with benzamidines the corresponding quinazolines are obtained.
