1280692-47-8Relevant academic research and scientific papers
Selective β-Arylation of Thiophenes with Aryl Iodides Catalyzed by Dinuclear Palladium Carboxylate Complexes
Maki, Yohei,Goto, Takahiro,Tsukada, Naofumi
, p. 699 - 702 (2016)
Novel dinuclear palladium complexes bearing acetoxy ligands were synthesized and characterized by X-ray crystal analysis. The complexes were utilized for the arylation of 2-ethylthiophene with iodobenzene to give ethylphenylthiophenes with high β selectiv
Oxidative biaryl coupling of thiophenes and thiazoles with arylboronic acids through palladium catalysis: Otherwise difficult C4-selective C-H arylation enabled by boronic acids
Kirchberg, Sylvia,Tani, Satoshi,Ueda, Kirika,Yamaguchi, Junichiro,Studer, Armido,Itami, Kenichiro
supporting information; experimental part, p. 2387 - 2391 (2011/04/21)
(Chemical Equation Presented) It adds up to 4! Thiophenes and thiazoles can be arylated in the 4- rather than the expected 5-position in a new C-H functionalization reaction (see scheme; TEMPO: 2,2,6,6-tetramethylpiperidine-N- oxyl). The boronic acid proved to be the key to achieving the otherwise difficult C4 selectivity. The method was applied to a concise synthesis of a key pharmacological structure with potential for treatment of Alzheimers disease.
