1280709-41-2Relevant academic research and scientific papers
Designer peptide dendrimers using click reaction
Haridas,Sharma, Yogesh K.,Sahu, Srikanta,Verma, Ram P.,Sadanandan, Sandhya,Kacheshwar, Bharat G.
experimental part, p. 1873 - 1884 (2011/04/17)
We designed and synthesized various peptide dendrimers using a 1,3-dipolar cycloaddition (Click) reaction. The dendritic structures reported here include symmetrical, asymmetrical, and cationic dendrimers with triazole, cystine, aromatic, aliphatic, and Lys-Asp dipeptide cores. The high chemoselectivity of the click reaction allowed us to synthesize good yields of high-purity protected and unprotected dendritic structures. Triazole is an excellent peptide bond mimic, which remains hydrolytically stable. Dendrimer 15a and the core unit 21 gelate in a mixture of organic solvents. We also demonstrated the versatility of the design by synthesizing various carbohydrate-based dendrimers.
