1280786-96-0

Basic information

• Product Name: 1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine
• Synonyms: 1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine;1-Bromo-4-(1-phenyl-1-pyrrolidinomethyl)benzene
• CAS NO: 1280786-96-0
• Molecular Formula: C17H18BrN
• Molecular Weight: 316.23552
• Mol File: 1280786-96-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 381.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.328±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.68±0.20(Predicted)
• CAS DataBase Reference: 1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine(1280786-96-0)
• EPA Substance Registry System: 1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine(1280786-96-0)

Safety Data

• Hazardous Substances Data: 1280786-96-0(Hazardous Substances Data)

Usage

General Description

1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine is a chemical compound that consists of a pyrrolidine ring with a phenyl, bromophenyl, and phenylmethyl substituents attached. It is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various drugs and biologically active compounds. The presence of the bromophenyl group makes this compound potentially useful in medicinal chemistry, as bromine atoms can enhance the biological activity of some molecules. Additionally, the phenylmethyl group provides a versatile functional group for further chemical modification and manipulation of the compound's properties. Overall, 1-((4-Bromophenyl)(phenyl)methyl)pyrrolidine has potential applications in drug discovery and development due to its structural features and reactivity.

Upstream product

• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 29334-16-5 phenyl(4-bromophenyl)methanol 
• 123-75-1 pyrrolidine 
• 13391-38-3 4-bromo-benzhydryl chloride 

Relevant articles and documents

Synthesis and biological evaluation of 1‐(Diarylmethyl)‐1h‐1,2,4‐triazoles and 1‐(diarylmethyl)‐1h‐imidazoles as a novel class of anti‐mitotic agent for activity in breast cancer

We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)‐positive MCF‐7 breast cancer cells identified 5‐((2H‐1,2,3‐triazol‐1‐yl)(3,4,5‐trimethoxyphenyl)methyl)‐2‐methoxyphenol 24 as a potent antiproliferative compound with an IC50 value of 52 nM in MCF‐7 breast cancer cells (ER+/PR+) and 74 nM in triple‐negative MDA‐MB‐231 breast cancer cells. The compounds demonstrated significant G2/M phase cell cycle arrest and induction of apoptosis in the MCF‐7 cell line, inhibited tubulin polymerisation, and were selective for cancer cells when evaluated in non-tumorigenic MCF‐10A breast cells. The immunofluorescence staining of MCF‐7 cells confirmed that the compounds targeted tubulin and induced multinucleation, which is a recognised sign of mitotic catastrophe. Computational docking studies of compounds 19e, 21l, and 24 in the colchicine binding site of tubulin indicated potential binding conformations for the compounds. Compounds 19e and 21l were also shown to selectively inhibit aromatase. These compounds are promising candidates for development as antiproliferative, aromatase inhibitory, and microtubule‐disrupting agents for breast cancer.