128099-74-1

Basic information

• Product Name: 1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE
• Synonyms: 1,3-Bis-(2,3-dihydro-indol-1-yl)-propane-1,3-dione; 1,3-di(2,3-dihydro-1H-indol-1-yl)propane-1,3-dione
• CAS NO: 128099-74-1
• Molecular Formula: C19H18N2O2
• Molecular Weight: 306.37
• Mol File: 128099-74-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 626.2°C at 760 mmHg
• Flash Point: 315.6°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 1.35E-15mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE(128099-74-1)
• EPA Substance Registry System: 1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE(128099-74-1)

Safety Data

• Hazardous Substances Data: 128099-74-1(Hazardous Substances Data)

Usage

General Description

1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE is a chemical compound with the molecular formula C18H18N2O2. It is also known by the name "dimedone". 1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE is a diketone that is commonly used in organic synthesis as a precursor for various heterocyclic and carbocyclic compounds. It is also used as a reagent in the synthesis of pharmaceuticals and in the preparation of dyes and polymers. 1,3-BIS-(2,3-DIHYDRO-INDOL-1-YL)-PROPANE-1,3-DIONE is a versatile compound with a wide range of applications in the field of organic chemistry.

InChI:InChI=1/C19H18N2O2/c22-18(20-11-9-14-5-1-3-7-16(14)20)13-19(23)21-12-10-15-6-2-4-8-17(15)21/h1-8H,9-13H2

Upstream product

• 496-15-1 1-indoline 
• 105-53-3 diethyl malonate 
• 1663-67-8 malonoyl dichloride 

Downstream Products

• 128099-82-1 5-chloro-5-nitro-1,2,5,6-tetrahydro-4H-pyrrolo<3,2,1-ij>quinoline-4,6-dione 
• 128099-81-0 6-hydroxy-5-nitro-1,2-dihydro-4H-pyrrolo<3,2,1-ij>quinolin-4-one 
• 128099-83-2 5,5-dichloro-1,2,5,6-tetrahydro-4H-pyrrolo<3,2,1-ij>quinoline-4,6-dione 

Relevant articles and documents

Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1

We present the design, synthesis and biological activity of a new series of substituted 3-(2-(1H-indol-1-yl)ethyl)-1H-indoles and 1,2-di(1H-indol-1-yl)alkanes as selective inhibitors of CDK4/cyclin D1. The compounds were designed to explore the relationship between the connection mode of the indolyl moieties and their CDK inhibitory activities. We found all the above-mentioned designed compounds to be selective inhibitors of CDK4/cyclin D1 compared to the closely related CDK2/cyclin A, with IC50 for the best compounds 10m and 13a being 39 and 37 μm, respectively.