128104-39-2

Basic information

• Product Name: BENZENEETHANIMIDAMIDE, N-HYDROXY-3-(TRIFLUOROMETHYL)
• Synonyms: BENZENEETHANIMIDAMIDE, N-HYDROXY-3-(TRIFLUOROMETHYL)
• CAS NO: 128104-39-2
• Molecular Formula: C₉H₉F₃N₂O
• Molecular Weight: 218.18
• Mol File: 128104-39-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZENEETHANIMIDAMIDE, N-HYDROXY-3-(TRIFLUOROMETHYL)(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEETHANIMIDAMIDE, N-HYDROXY-3-(TRIFLUOROMETHYL)(128104-39-2)
• EPA Substance Registry System: BENZENEETHANIMIDAMIDE, N-HYDROXY-3-(TRIFLUOROMETHYL)(128104-39-2)

Safety Data

• Hazardous Substances Data: 128104-39-2(Hazardous Substances Data)

Upstream product

• 2338-76-3 3-trifluoromethylphenylacetonitrile 

Downstream Products

• 128104-43-8 4-[[(3-trifluoromethyl)phenyl]methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide 
• 1027029-42-0 (S)-1-[3-(3-Trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-ethylamine 

Relevant articles and documents

NOVEL COMPOUNDS AND THEIR USE IN THERAPY

The invention provides compounds which inhibit N-myristoyltransferase and are selective for protozoal N-myristoyltransferase and, consequently suitable to treat microbial infections, including viral and fungal infections, and protozoan infections such as malaria, leishmaniasis and sleeping sickness.

Antihyperglycemic activity of novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides

A series of substituted 3H-1,2,3,5-oxathiadiazole-2-oxides (6) was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. The oxathiadiazoles 6 were synthesized by a two-step sequence: treatment of a substituted acetonitrile (4) with hydroxylamine to give the corresponding amidoxime (5) and cyclization with thionyl chloride to yield 6. In terms of potency, the 2-naphthalenylmethyl group (as in compound 3) was found to be the optimal substituent in this series. Compound 3 was approximately 5 times more potent than ciglitazone (1).