128104-44-9

Basic information

• Product Name: 3H-1,2,3,5-Oxathiadiazole, 4-[(4-bromo-2-fluorophenyl)methyl]-, 2-oxide
• CAS NO: 128104-44-9
• Molecular Formula: C8H6BrFN2O2S
• Molecular Weight: 293.116
• Mol File: 128104-44-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3H-1,2,3,5-Oxathiadiazole, 4-[(4-bromo-2-fluorophenyl)methyl]-, 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,3,5-Oxathiadiazole, 4-[(4-bromo-2-fluorophenyl)methyl]-, 2-oxide(128104-44-9)
• EPA Substance Registry System: 3H-1,2,3,5-Oxathiadiazole, 4-[(4-bromo-2-fluorophenyl)methyl]-, 2-oxide(128104-44-9)

Safety Data

• Hazardous Substances Data: 128104-44-9(Hazardous Substances Data)

Upstream product

• 114897-91-5 (4-bromo-2-fluorophenyl)acetonitrile 
• 128104-38-1 2-(4-Bromo-2-fluoro-phenyl)-N-hydroxy-acetamidine 

Relevant articles and documents

Antihyperglycemic activity of novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides

A series of substituted 3H-1,2,3,5-oxathiadiazole-2-oxides (6) was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. The oxathiadiazoles 6 were synthesized by a two-step sequence: treatment of a substituted acetonitrile (4) with hydroxylamine to give the corresponding amidoxime (5) and cyclization with thionyl chloride to yield 6. In terms of potency, the 2-naphthalenylmethyl group (as in compound 3) was found to be the optimal substituent in this series. Compound 3 was approximately 5 times more potent than ciglitazone (1).