128113-90-6Relevant academic research and scientific papers
CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes
Zhou, Yujing,Engl, Oliver D.,Bandar, Jeffrey S.,Chant, Emma D.,Buchwald, Stephen L.
, p. 6672 - 6675 (2018)
A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.
