128119-51-7

Basic information

• Product Name: C₂₇H₂₇O₁₈P₃
• Synonyms: C₂₇H₂₇O₁₈P₃
• CAS NO: 128119-51-7
• Molecular Weight: 732.422
• Mol File: 128119-51-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₇O₁₈P₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₇O₁₈P₃(128119-51-7)
• EPA Substance Registry System: C₂₇H₂₇O₁₈P₃(128119-51-7)

Safety Data

• Hazardous Substances Data: 128119-51-7(Hazardous Substances Data)

Upstream product

• 454199-97-4 L-1,2,6-tri-O-benzoyl-4,5-O-isopropylidene-myo-inositol 
• 454200-06-7 L-1,6-di-O-benzoyl-3,4-O-isopropylidene-myo-inositol 
• 455268-36-7 L-1,2,6-tri-O-benzoyl-myo-inositol 
• 165883-87-4 L-1,6-di-O-benzoyl-myo-inositol 
• 136845-94-8 1,3,4-tri-O-benzoyl-D-myo-inositol 
• 454198-56-2 L-1,3,6-tri-O-benzoyl-myo-inositol 2,4,5-tris(diethyl phosphate) 
• 120691-49-8 2,4,5-tris-O-(dibenzyloxyphosphinyl)-1,3,6-tri-O-benzoyl-L-myo-inositol 
• 120691-49-8 1,3,4-tris-O-(dibenzyloxyphosphinyl)-2,5,6-tri-O-benzoyl-D-chiro-inositol 
• 454198-30-2 D-1,2,6-tri-O-benzoyl-4,5-O-isopropylidene-myo-inositol 
• 455268-34-5 D-1,2,6-tri-O-benzoyl-myo-inositol 
• 454199-11-2 D-1,6-di-O-benzoyl-3,4-O-isopropylidene-myo-inositol 
• 454198-20-0 D-1,6-di-O-benzoyl-2,3:4,5-di-O-isopropylidene-myo-inositol 
• 454198-21-1 D-1,6-di-O-benzoyl-2,3-O-isopropylidene-myo-inositol 
• 454198-22-2 D-1,6-di-O-benzoyl-myo-inositol 

Downstream Products

• 92216-45-0 D-myo-inositol 2,4,5-trisphosphate 
• 108340-81-4 L-myo-inositol 2,4,5-trisphosphate hexasodium salt 
• 108340-81-4 C₆H₉O₁₅P₃^(6-)*6Na⁽¹⁺⁾ 
• 108340-81-4 C₆H₉O₁₅P₃^(6-)*6Na⁽¹⁺⁾ 
• 108340-81-4 D-myo-inositol 2,4,5-trisphosphate hexasodium salt 

Relevant articles and documents

Divergent syntheses of all possible optically active regioisomers of myo-inositol tris- and tetrakisphosphates

Since the discovery of D-myo-inositol 1,4,5-trisphosphate, which plays a pivotal role as a second messenger in transmembrane signaling, the scope of the phosphoinositide-based signaling processes has been continually expanding. However, the clear understanding of the molecular signal transduction mechanisms including the functions of newly found IPn is still lacking. As a continuing effort to our previously reported syntheses of all possible 39 optically inactive regioisomers of myoinositol phosphates (IPn; n = 1-6), we synthesized all possible optically active regioisomers of myo-IP3 and myo-IP4 using chiral IBz3s and IBz2s, respectively. A series of procedures involving CRL-catalyzed enzymatic resolution of racemic 1,2:5,6-di-O-isopropylidene-myo-inositol and base-catalyzed benzoyl migration in tri- and dibenzoyl-isopropylidene-myo-inositol afforded eight enantiomeric pairs of IBz3 and six enantiomeric pairs of IBz2, respectively. Phosphorylation of these intermediates by the phosphitylation and oxidation procedure gave the target products.

Synthesis and Ca2+-release activity of D- and L-myo-inositol 2,4,5-trisphosphate and D- and L-chiro-inositol 1,3,4-trisphosphate

Partial benzoylation of the 3,4-dibenzyl ethers of D- and L-chiro-inositol provided the 1,2,5-tri-O-benzoyl-3,4-di-O-benzyl-chiro-inositols. Inversion of the free axial hydroxyl group gave a mixture of chiral 1,3,4- and 1,2,4-tri-O-benzoyl-5,6-di-O-benzyl