128120-95-6Relevant academic research and scientific papers
β-lactam derivatives as enzyme inhibitors: Derivatives of (E)-2-[(RS)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-ylidene]propionic acid
Venz,Otto
, p. 686 - 690 (2007/10/03)
The 1,4-diaryl disubstituted azetidin-2-one (β-lactam) 1 is transformed into the 3-methylidene derivative (E)-2-[(RS)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-ylidene]propionic acid (3), and then, using the DCC/NHS method reacted with amino acid esters and dipeptide esters forming 3-(peptidyl)-β-lactams 5 and 7. Structures and properties are evaluated mainly by spectroscopic methods and discussed. As molecular modeling experiments might suggest a potential activity as inhibitors of PPE(HLE), a number of selected compounds has been tested in an enzyme assay. But none of them showed any remarkable inhibitory activity. Evaluation of the data was done with the new program EnKinPlot.
ONE POT SYNTHESIS AND CONFORMATION OF N-t-BUTYLOXYCARBONYL, O-PHENACYL DERIVATIVES OF PROLINE AND OTHER SECONDARY AMINO ACIDS.
Hondrelis, John,Lonergan, Greg,Voliotis, Stavros,Matsoukas, John
, p. 565 - 576 (2007/10/02)
Proline, 4-hydroxyproline, azetidine-2-carboxylic acid, pipecolic acid and proline containing dipeptides were converted to N-t-butyloxycarbonyl, O-phenacyl derivatives in a one pot synthesis. 1H- and 13C-NMR spectroscopy of certain derivatives (Boc-Pro-PE
