128146-92-9

Upstream product

• 128073-33-6 2,2-difluoro-1-methyl-1-cyclopropanecarboxylic acid 

Downstream Products

• 128230-75-1 2,2-Difluoro-1-methylcyclopropanecarboxylic acid amide 
• 139297-66-8 2-chlorobenzyl (2,2-difluoro-1-methyl)-cyclopropyl ketone 
• 1354043-36-9 C₂₂H₁₈F₃N₇O₂ 
• 1234619-44-3 N-{(7R)-6-Cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]-triazolo[1,5-a]pyrimidin-2-yl}-2,2-difluoro-1-methylcyclopropanecarboxamide 

Relevant academic research and scientific papers

SGC STIMULATORS

Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

2,2-difluorocyclopropyl derivatives

2,2-Difluorocyclopropyl derivatives of the formula STR1 in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl and X represents hydroxymethyl, 2-hydroxyethyl, isocyanato, amino, amino hydrohalide or a radical of the for

Hydroxyalkinyl-azolyl derivatives

Novel hydroxyalkinyl-azolyl derivatives of the formula STR1 in which Ar represents optionally substituted aryl, R represents alkyl, optionally substituted aryl or optionally substituted aralkyl, X1 represents halogen, X2 represents hydrogen or halogen, X3 represents hydrogen or halogen, X4 represents hydrogen or halogen and n represents 0 or 1, and acid addition salts and metal salt complexes thereof, are outstandingly effective as fungicides.

Fluorinated cyclopropanecarboxylic acids and their derivatives

The addition of halofluorocarbenes such as :CF2, :CClF or :CBrF, generated from the appropriate halofluoromethanes with bases, to butadiene or isoprene gives the corresponding l-vinyl substituted halofluorocyclopropanes in moderate to good yield. The vinyl group facilitates the carbene addition and permits a subsequent wide derivatisation. Several transformations including hydroboration, oxidation and Curtius degradation are presented. Furthermore, replacement of the chlorine atom in 2-chloro-2-fluorocyclopropanecarboxylic acid derivatives by hydrogen is achieved catalytically with Raney nickel. This sequence provides a convenient route to mono-fluorine substituted cyclopropane carboxylic acids.