128156-28-5

Upstream product

• 141-97-9 ethyl acetoacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5447-76-7 ethyl 3-oxobutanate oxime 

Downstream Products

• 128156-51-4 4,4'-Bis-(3,4-dimethoxy-benzyl)-3,3'-dimethyl-4H,4'H-[4,4']biisoxazolyl-5,5'-dione 
• 128156-34-3 4-(3,4-Dimethoxy-benzyl)-3-methyl-2H-isoxazol-5-one 
• 6302-60-9 4-(3,4-dimethoxy-phenyl)-butan-2-one 

Relevant academic research and scientific papers

Cu/TCH-pr&at;SBA-15 nano-composite: A new organometallic catalyst for facile three-component synthesis of 4-arylidene-isoxazolidinones

A copper complex supported on SBA-15 nanoparticles (Cu/TCH-pr&at;SBA-15) was synthesized by the post-synthesis modification of nano-mesoporous silica with 3-chloropropyltriethoxysilane (CPTES) and thiocarbohydrazide (TCH) and subsequent metal-ligand coord

Pyruvic acid-catalyzed one-pot three-component green synthesis of isoxazoles in aqueous medium: a comparable study of conventional heating versus ultra-sonication

A mild and efficient route for the one-pot synthesis of isoxazole derivatives has been developed using pyruvic acid as a catalyst under an aqueous medium. The reaction was carried out under conventional as well as ultrasonic conditions to afford the desir

A simple and efficient protocol for the synthesis of 3,4-disubstituted isoxazol-5(4h)-ones catalyzed by succinic acid using water as green reaction medium

A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium

An efficient solvent-free synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using microwave irradiation

I have reported one-pot and three-component synthesis of 3-mehyl-4-arylmethyleneisoxazol-5(4H)-ones using microwave radiation under the solvent-free conditions, in the presence of potassium bromide as the catalyst. The method has given the products in hig

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

An expeditious synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-ones using aqueous extract of acacia concinna pods as a natural surfactant catalyst

An aqueous extract of Acacia concinna pods has been employed as a competent and effective natural surfactant type catalyst for the synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-one analogs through one-pot, three-component reaction of β-ketoester,

A novel dicationic ionic liquid as a highly effectual and dual-functional catalyst for the synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-ones

Abstract: A novel dicationic ionic liquid, N,N,N′,N′-tetramethyl-N,N′-bis(sulfo)ethane-1,2-diaminium mesylate [TMBSED][OMs]2), has been produced, and identified by analysis of its 1H NMR, 13C NMR, FT-IR, mass and thermal g

Sonochemical synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones by amine-modified montmorillonite nanoclay

Ultrasound irradiation was applied for the rapid and clean synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones through condensation of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives. This methodology was effectively ca

DABCO functionalized dicationic ionic liquid (DDIL): A novel green benchmark in multicomponent synthesis of heterocyclic scaffolds under sustainable reaction conditions

A novel DABCO functionalized dicationic ionic liquid (DDIL) has been synthesized using diazabicyclo[2,2,2]octane (DABCO), 1,3-dichloro-2-propanol and NaBF4 in acetonitrile. The IL was fully characterized by IR, NMR and mass spectroscopic techniques. The presence of BF4? anion in IL was confirmed by 19F NMR and also supported by mass analysis. The TGA analysis showed that the IL is thermally stable up to 180?°C temperature. We demonstrated that the presence of the tertiary nitrogen sites and hydroxyl group in the DDIL network enhances the overall activity of DDIL. These make them compatible for base catalyzed one pot multicomponent synthesis of ortho-amino carbonitriles and 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones under grinding without solvent. In addition the activity of DDIL was also studied for synthesis of tetrahydrobenzo[b]pyrans under ultrasound irradiation in water. Furthermore the DDIL was easily recoverable and recyclable many times with modest decrease in activity.