1281753-80-7

Basic information

• Product Name: N-(4-chlorophenyl)-2-[4-(4-fluorophenoxy)benzylidene]hydrazinecarbothioamide
• Synonyms: N-(4-chlorophenyl)-2-[4-(4-fluorophenoxy)benzylidene]hydrazinecarbothioamide
• CAS NO: 1281753-80-7
• Molecular Weight: 399.876
• Mol File: 1281753-80-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-2-[4-(4-fluorophenoxy)benzylidene]hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-2-[4-(4-fluorophenoxy)benzylidene]hydrazinecarbothioamide(1281753-80-7)
• EPA Substance Registry System: N-(4-chlorophenyl)-2-[4-(4-fluorophenoxy)benzylidene]hydrazinecarbothioamide(1281753-80-7)

Safety Data

• Hazardous Substances Data: 1281753-80-7(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 459-57-4 4-fluorobenzaldehyde 
• 22814-92-2 4-(p-chlorophenyl)-3-thiosemicarbazide 
• 137736-06-2 4-(4-fluorophenoxy)benzaldehyde 
• 371-41-5 4-Fluorophenol 

Relevant articles and documents

Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides

Thirty six new N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothioamides were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established in three seizure models i.e. MES, scMET and 6 Hz model. The most active compound was 2-[4-(4-chlorophenoxy)benzylidene]-N-(4-fluorophenyl) hydrazinecarbothioamide PC 31 which showed 100% protection at 0.5 h in the 6 Hz test. Compound 2-[4-(4-bromophenoxy) benzylidene]-N-(4-bromophenyl) hydrazinecarbothioamide PC 23 was found to be active in both the MES and 6 Hz test. A computational study was carried out from calculation of a pharmacophore pattern and the prediction of pharmacokinetic properties. Titled compounds have also exhibited good binding properties with epilepsy molecular targets such as glutamate, GABA (A) delta and GABA (A) alpha-1 receptors, in the Lamarckian genetic algorithm based on flexible docking studies.