128176-64-7Relevant academic research and scientific papers
Direct18F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F-on Phosphonate Prostheses
Wang, Chao,Zhang, Lei,Mou, Zhaobiao,Feng, Wanru,Li, Zhongjing,Yang, Hongzhang,Chen, Xueyuan,Lv, Shengji,Li, Zijing
supporting information, p. 4261 - 4266 (2021/05/26)
We describe a high radiochemical yield late-stage direct 18F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other electrophiles by F- at various hydrogen bond forms. Rapid access to many medicinally significant 18F-labeled biomolecules is achieved at 21-68% radiochemical yields and 35.9-55.1 GBq μmol-1 molar activities both manually or automatically.
Synthesis and characterization of a phosphorus-containing flame retardant with double bonds and its application in bismaleimide resins
Li, Song,Yan, Hongxia,Feng, Shuyao,Niu, Song
, p. 101480 - 101486 (2015/12/08)
A novel phosphorus-containing flame retardant, bis(4-(allyloxy)phenyl)phenylphosphonate (APP) has been synthesized. The structure of APP has been systemically characterized using Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonanc
Nonlinear Broensted Relationships in the Reaction of Phenoxide Ions with Bis(4-nitrophenyl) Phenylphosphonate in H2O-Me2SO Mixtures. Solvation Effects
Terrier, Francois,Moutiers, Gilles,Xiao, Lan,Guevel, Eric Le,Guir, Frederic
, p. 1748 - 1754 (2007/10/02)
The second-order rate constants (kArO) for reaction of substituted phenoxide ions with bis(4-nitrophenyl) phenylphosphonate in aqueous as well as vatious aqueous dimethyl sulfoxide (Me2SO) mixtures are reported.Traditional Broensted plots of log kArO vs pKArOHa are linear at low pKArOHa but show very strong downward curvature at high pKArOHa.In each solvent, the break point in the Broensted plot occurs at a pKArOHa value which is much higher than that corresponding to the basicity of the leaving p-nitrophenoxide ion, suggesting that the observed levelling off does not reflect a change in the identity of the rate-determining step in a two-step process involving formation of a pentacoordinate intermediate.An analysis of the data on the basis of a novel strategy recently designed by Buncel and co-workers for the construction of Broensted plots in solvent mixtures confirms this conclusion.It is proposed that the curvature in the traditional Broensted plots is the reflection of strong imbalances in the transition states of the reactions, and it is suggested that these imbalances are essentially of solvational nature.
PHOTOLYSIS OF ARYL ESTERS OF TRI- AND TETRACOORDINATED PHOSPHORUS COMPOUNDS
Shi, Min,Yamamoto, Kiichi,Okamoto, Yoshiki,Takamuku, Setsuo
, p. 1 - 14 (2007/10/02)
Upon UV excitation in methanol, some diaryl esters of alkly- or alkenyl phosphonates underwent an elimination of two aryl groups to give biaryls and the corresponding alkyl- or alkenylphosphonic acids.Tris(4-methoxyphenyl) phosphite also underwent a similar elimination to give 4,4'-dimethoxybiphenyl and 4-methoxyphenyl phosphonate.This interesting biaryl elimination was confirmed to proceed via a singlet intramolecular excimer by means of fluorescence spectra and Stern-Volmer analysis.
