1281969-69-4Relevant academic research and scientific papers
Nickel-catalyzed selective conversion of two different aldehydes to cross-coupled esters
Hoshimoto, Yoichi,Ohashi, Masato,Ogoshi, Sensuke
supporting information; experimental part, p. 4668 - 4671 (2011/05/16)
In the presence of a Ni(0)/NHC catalyst, an equimolar mixture of aliphatic and aryl aldehydes can be employed to selectively yield a single cross-coupled ester. This reaction can be applied to a variety of aliphatic (1°, 2°, cyc-2°, and 3°) and aryl aldehyde combinations. The reaction represents 100% atom efficiency and generates no waste. Mechanistic studies have revealed that the striking feature of the reaction is the simultaneous coordination of two aldehydes to Ni(0).
