1282035-02-2Relevant academic research and scientific papers
Rational design of β-sheet ligands against Aβ42- induced toxicity
Hochdoerffer, Katrin,Maerz-Berberich, Julia,Nagel-Steger, Luitgard,Epple, Matthias,Meyer-Zaika, Wolfgang,Horn, Anselm H.C.,Sticht, Heinrich,Sinha, Sharmistha,Bitan, Gal,Schrader, Thomas
, p. 4348 - 4358 (2011)
A β-sheet-binding scaffold was equipped with long-range chemical groups for tertiary contacts toward specific regions of the Alzheimer's Aβ fibril. The new constructs contain a trimeric aminopyrazole carboxylic acid, elongated with a C-terminal binding si
NEW COMPOUNDS FOR THE TREATMENT OF DISEASES RELATED TO PROTEIN MISFOLDING
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Page/Page column 73; 74, (2011/05/11)
The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformat
