128204-35-3

Upstream product

• 85692-37-1 1-(1-methyl-1H-imidazol-2-yl)ethan-1-one 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1315282-08-6 C₂₄H₂₁FN₄O₄ 
• 1227008-98-1 (2S,3S)-methyl 3-(4-fluorophenyl)-2-hydroxy-5-(1-methyl-1H-imidazol-2-yl)-5-oxo-2-phenylpentanoate 

Relevant academic research and scientific papers

Asymmetric Synthesis of Multi-Substituted Tetrahydrofurans via Palladium/Rhodium Synergistic Catalyzed [3+2] Decarboxylative Cycloaddition of Vinylethylene Carbonates

Unlike the comprehensive development of tandem multi-metallic catalysis, bimetallic synergistic catalysis has been challenging to achieve high stereoselectivity with the generation of multi-stereogenic centers. Herein, an efficient synergistic catalysis for the diastereo- and enantioselective synthesis of multi-substituted tetrahydrofuran derivatives has been developed. Under mild reaction conditions, a series of target molecules with three consecutive stereocenters were synthesized by a palladium(0)/rhodium(III) bimetal-catalyzed asymmetric decarboxylative [3+2]-cycloaddition of vinylethylene carbonates with α,β-unsaturated carbonyl compounds. The corresponding adducts were obtained with moderate to high yields (67 %～98 %) and excellent stereoselectivities (>20 : 1 d.r., up to 99 % ee).