1282040-40-7Relevant academic research and scientific papers
Direct Synthesis of CF2H-Substituted 2-Amidofurans via Copper-Catalyzed Addition of Difluorinated Diazoacetone to Ynamides
Zheng, Yongxiang,Perfetto, Anna,Luise, Davide,Ciofini, Ilaria,Miesch, Laurence
, p. 5528 - 5532 (2021)
The significance of molecules containing difluoromethyl groups is driven by their potential applications in pharmaceutical and agrochemical science. Methods for the incorporation of lightly fluorinated groups such as CF2H have been less well developed. He
Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines
Garcia, Pierre,Evanno, Yannick,George, Pascal,Sevrin, Mireille,Ricci, Gino,Malacria, Max,Auber, C. Torinne,Gandon, Vincent
supporting information; experimental part, p. 2030 - 2033 (2011/06/23)
Bimolecular cobalt-catalyzed [2+2+2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion.
