1282061-03-3

Upstream product

• 1001-75-8 4-methyl-4-pentenoic acid 
• 1071-85-8 1-oxo-4-methyl-4-pentenyl chloride 
• 106-49-0 p-toluidine 
• 2258-59-5 4-methyl-4-pentenoic acid methyl ester 

Downstream Products

• 1453416-15-3 4,5-dihydroxy-4-methyl-N-p-tolylpentanamide 

Relevant academic research and scientific papers

Study on the total synthesis of velbanamine: Chemoselective dioxygenation of alkenes with PIFA via a stop-and-flow strategy

A "stop-and-flow" strategy was developed for the chemoselective dioxygenation of alkenes with a PIFA-initiated cyclization. This method is conceived for the desymmetrization of seco-diene, and a series of substituted 5-hydroxymethyl-γ-lactones were constructed after hydrolysis. This strategy also differentiates terminally substituted alkenes and constitutes a potentially novel synthetic approach for the efficient synthesis toward velbanamine.

Pd(II)-catalyzed intramolecular amidoarylation of alkenes with molecular oxygen as sole oxidant

Stereoselective palladium-catalyzed synthesis of structurally versatile indoline derivatives, using molecular oxygen as the sole oxidant, is described. New C-N and C-C bonds form across an alkene in an intramolecular manner. The C-N bond-forming step proceeds via a syn-amidopalladation pathway. The moderate kinetic isotope effects (intramolecular KIE = 3.56) suggest that electrophilic aromatic substitution occurs in the arylation step.