128209-98-3

Upstream product

• 119711-55-6 N-cyclohexylimine of 2-triethylsilylpropionaldehyde 
• 128209-97-2 (1R,3R,4R)-4-[(tert-butyldimethylsilyl)oxy]-3-methoxycyclohexane-1-carbaldehyde 
• 5709-98-8 (R)-cyclohex-3-enecarboxylic acid 
• 116498-92-1 (1R,4R,5R)-4-hydroxy-6-oxabicyclo[3.2.1]octan-7-one 
• 127604-95-9 (1R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-oxa-bicyclo[3.2.1]octan-7-one 
• 127604-96-0 (1R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-cyclohexanecarboxylic acid methyl ester 
• 127604-97-1 methyl (1R,3R,4R)-4-[(tert-butyldimethylsilyl)oxy]-3-methoxycyclohexane-1-carboxylate 
• 127604-94-8 3-Cyclohexene-1-carboxylic acid (S)-pantolactone ester 

Downstream Products

• 127605-01-0 (E)-(2S,3S)-5-[(1R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-3-hydroxy-2,4-dimethyl-pent-4-enethioic acid S-phenyl ester 
• 127605-03-2 (E)-(2S,3S)-5-[(1R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-3-methoxymethoxy-2,4-dimethyl-pent-4-enal 
• 127623-75-0 Acetic acid (E)-(3S,4R,5S)-7-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-3-hydroxy-5-methoxymethoxy-4,6-dimethyl-1-methylene-hept-6-enyl ester 
• 127605-02-1 (E)-(2S,3S)-5-[(1R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-3-methoxymethoxy-2,4-dimethyl-pent-4-enethioic acid S-phenyl ester 
• 127605-06-5 (E)-(4S,5S,6S)-1-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-8-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-6-methoxymethoxy-5,7-dimethyl-oct-7-en-2-one 
• 127605-05-4 Acetic acid (E)-(3S,4S,5S)-3-(tert-butyl-dimethyl-silanyloxy)-7-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-5-methoxymethoxy-4,6-dimethyl-1-methylene-hept-6-enyl ester 
• 127605-08-7 (1E,8E,10E)-(3S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-3-methoxymethoxy-2,4,10,12-tetramethyl-trideca-1,8,10-trien-7-one 
• 127605-07-6 (E)-(4S,5S,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-(dimethyl-phenyl-λ⁵-phosphanylidene)-6-methoxymethoxy-5,7-dimethyl-oct-7-en-2-one 

Relevant academic research and scientific papers

ENANTIOSELECTIVE SYNTHESIS OF THE C(18)-C(35) SEGMENT OF IMMUNOSUPPRESSANT FK-506 USING EFFICIENT NEW METHODOLOGY

A simple, enantiocontrolled and efficient route to an intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-506 (1) is described which depends on a sequence of three enantioselective C-C bond forming reactions.