128225-23-0

Basic information

• Product Name: N-Methyl-N-<2-(4-pyridyl)ethyl>-(2-pyridyl)ethylamine
• Synonyms: N-Methyl-N-<2-(4-pyridyl)ethyl>-(2-pyridyl)ethylamine
• CAS NO: 128225-23-0
• Molecular Weight: 241.336
• Mol File: 128225-23-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Methyl-N-<2-(4-pyridyl)ethyl>-(2-pyridyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-<2-(4-pyridyl)ethyl>-(2-pyridyl)ethylamine(128225-23-0)
• EPA Substance Registry System: N-Methyl-N-<2-(4-pyridyl)ethyl>-(2-pyridyl)ethylamine(128225-23-0)

Safety Data

• Hazardous Substances Data: 128225-23-0(Hazardous Substances Data)

Upstream product

• 100-43-6 4-vinylpyridine 
• 5638-76-6 betahistine 

Relevant articles and documents

Nucleophilic Addition of 2-, 3-, or 4-pyridine to the Aziridine, 7-Methyl-7-azabicycloheptane

The synthesis of trans-(+/-)-N-methyl-N-amino>cyclohexyl>-4-benzofuranacetamide dihydrochloride, 1 which is a 3-pyridyl derivative of the kappa opioid analgesic trans-(+/-)-N-methyl-N-benzofuran-4-acetamide monohydrochloride, 2 is described.The key intermediate is trans-(+/-)-N,N'-dimethyl-N--1,2-cyclohexanediamine, 9 which is formed by nucleophilic addition of 3-pyridine 6 to the aziridine, 7-methyl-7-azabicycloheptane, 4.During attempts to prepare the 2- or 4-isomeric pyridyl derivatives of 1 it was discovered that both 2- or 4-pyridine, 5 or 7 are converted to N-methyl-N,N-di- 11 and N-methyl-N,N-di 13 respectively by refluxing in toluene in the presence of ammonium chloride.The 3-isomer, 6 is unchanged after treatment under identical conditions.Careful control of the reaction conditions enabled the aziridine 4 to be ring opened with the pyridyl amines 5 or 7 to give the 1,2-diamines trans-(+/-)-N,N'-dimethyl-N--1,2-cyclohexanediamine, 8 or trans-(+/-)-N,N'-dimethyl-N--1,2-cyclohexane diamine 10 respectively.