128225-66-1

Basic information

• Product Name: 3-(Difluoromethyl)-4-formyl-1-methyl-1H-pyrazole
• Synonyms: 3-(Difluoromethyl)-4-formyl-1-methyl-1H-pyrazole;1-methyl-3-(trifluoromethyl)-1h-pyrazole-4-carbaldehyde;1-Methyl-3-(trifluoromethyl)
• CAS NO: 128225-66-1
• Molecular Formula: C6H6F2N2O
• Molecular Weight: 160.122
• EINECS: 1312995-182-4
• Product Categories: Building Blocks;Pyrazole
• Mol File: 128225-66-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 231.987 °C at 760 mmHg
• Flash Point: 94.103 °C
• Appearance: Colourless liquid
• Density: 1.407 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 3-(Difluoromethyl)-4-formyl-1-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Difluoromethyl)-4-formyl-1-methyl-1H-pyrazole(128225-66-1)
• EPA Substance Registry System: 3-(Difluoromethyl)-4-formyl-1-methyl-1H-pyrazole(128225-66-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 128225-66-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Upstream product

• 155377-19-8 ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate 
• 111493-74-4 ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 113100-53-1 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 540468-96-0 (1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol 

Relevant articles and documents

ANTIDIABETIC SPIROCHROMAN COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS

The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such,