128226-43-7

Basic information

• Product Name: 1-CHLORO-2,3-DIHYDRO-6-METHOXY-1H-INDENE
• Synonyms: 1-CHLORO-2,3-DIHYDRO-6-METHOXY-1H-INDENE
• CAS NO: 128226-43-7
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 0
• Mol File: 128226-43-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CHLORO-2,3-DIHYDRO-6-METHOXY-1H-INDENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-2,3-DIHYDRO-6-METHOXY-1H-INDENE(128226-43-7)
• EPA Substance Registry System: 1-CHLORO-2,3-DIHYDRO-6-METHOXY-1H-INDENE(128226-43-7)

Safety Data

• Hazardous Substances Data: 128226-43-7(Hazardous Substances Data)

Upstream product

• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 3469-09-8 6-methoxyindan-1-ol 

Downstream Products

• 935248-14-9 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine 
• 935248-15-0 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-piperazine 

Relevant articles and documents

Total Synthesis of (-)-Daphenylline

Total synthesis of (-)-daphenylline, a hexacyclic Daphniphyllum alkaloid, was achieved. Construction of the tricyclic DEF ring system was initiated by asymmetric Negishi coupling followed by an intramolecular Friedel-Crafts reaction. Installation of a side chain onto the tricyclic core was carried out through Sonogashira coupling, stereocontrolled Claisen rearrangement by taking advantage of the characteristic conformation of the tricyclic DEF core, and the stereoselective alkylation of a lactone. After the introduction of a glycine unit, the ABC ring system was stereoselectively constructed through intramolecular cycloaddition of the cyclic azomethine ylide.

Catalytic enantioselective Negishi reactions of racemic secondary benzylic halides

This report describes the first enantioselective cross-couplings of racemic secondary benzylic halides, specifically, nickel-catalyzed Negishi reactions of bromides and chlorides. The catalyst components are commercially available and air-stable, and the reaction is not highly oxygen- or moisture-sensitive (it can be set up in the air). The method has been applied to the catalytic enantioselective synthesis of intermediates employed by others in the generation of bioactive compounds (e.g., trikentrin A and an androgen receptor agonist). Copyright

Indoles

A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3, R4, and R5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.