128227-36-1

Upstream product

• 15681-48-8 lithium dimethylcuprate 
• 119588-69-1 (2S,3S)-3-[(2S,4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-oxirane-2-carboxylic acid 
• 917-54-4 methyllithium 
• 128300-06-1 (2S,3R)-3-[(2R,4R,5S)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-oxirane-2-carboxylic acid 
• 119588-68-0 (E)-3-[(2R,4R,5S)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propenal 

Downstream Products

• 129611-60-5 (2S,4S,5R)-4-Methyl-5-phenyl-3-p-toluenesulfonyl-2-<(1S,2R)-1-hydroxy-2-carbomethoxy>propyloxazolidine 
• 128227-37-2 (2S,3R)-3-Hydroxy-N-methoxy-2-methyl-3-[(2R,4R,5S)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propionamide 
• 128227-40-7 (2S,3S)-1-Methoxy-3-methyl-4-oxo-azetidine-2-carbaldehyde 
• 58107-41-8 N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide 
• 129611-55-8 Methyl (2R,3S)-2-methyl-3-benzyloxy-4-oxobutanoate 

Relevant academic research and scientific papers

Asymmetric synthesis of malic acid-type synthons VIA chiral norephedrine-derived oxazolidines

Polyoxygenated C4 synthons 5-7 are synthesized in enantiomerically pure form starting from ephedrine derived oxazolidines 2,4 and 13. The 1,4-benzylate addition to 2 and 4, the key step in the synthesis of 5 and 6, proceeds cleanly with almost

ASYMMETRIC SYNTHESIS OF 3,4-CIS-SUBSTITUTED β-LACTAMS VIA CHIRAL NOREPHEDRINE-DERIVED OXAZOLIDINES.

A diastereo- and enantioselective approach to functionalized 3,4-cis-β-lactams 9 and 16 was developed based on the use of chiral norephedrine-derived oxazolidines.The key-steps in the synthesis of 9 (Scheme 1) are the potassium hypochlorite epoxidation of