1282425-40-4Relevant academic research and scientific papers
α-N-Heteroarylation and α-Azidation of Ketones via Enolonium Species
More, Atul A.,Pathe, Gulab K.,Parida, Keshaba N.,Maksymenko, Shimon,Lipisa, Yuriy B.,Szpilman, Alex M.
, p. 2442 - 2447 (2018)
Enolonium species, resulting from the umpolung of ketone enolates by Koser's hypervalent iodine reagents activated by boron trifluoride, react with a variety of nitrogen heterocycles to form α-aminated ketones. The reactions are mild and complete in 4-5 h. Additionally, α-azidation of the enolonium species takes place using trimethylsilyl azide as a convenient source of azide nucleophile.
Synthesis of (Z)-N-alkenylazoles and pyrroloisoquinolines from α-N-azoleketones through Pd-catalyzed tosylhydrazone cross-couplings
Florentino, Lucia,Aznar, Fernando,Valdes, Carlos
supporting information, p. 10506 - 10510 (2013/08/23)
Azoles reacting in tandem: The ortho-stereodirecting effect is the key to the stereoselective synthesis of (Z)-N-alkenylazoles I through the tosylhydrazide-mediated Pd-catalyzed cross-coupling reaction of α-N-azoleacetophenones with ortho-substituted aryl halides and nonaflates (see scheme). Additionally, the preorganization of the alkene allowed for the development of an auto-tandem reaction involving an intramolecular C-H arylation leading to pyrroloisoquinolines II. Copyright
