1282521-53-2Relevant articles and documents
Catalytic enantioselective protonation of α-oxygenated ester enolates prepared through phospha-brook rearrangement
Hayashi, Masashi,Nakamura, Shuichi
, p. 2249 - 2252 (2011/04/16)
(Chemical Equation Presented) Phosphonates go chiral: The organocatalytic enantioselective reaction of α-ketoesters with phosphites using cinchona alkaloids and Na2CO3 has afforded α-phosphonyloxy esters with high enantioselectivities (see scheme). This process allows the formation of both enantiomers of the product. A catalyst loading of as low as 2 mol% does not result in a significant decrease of the enantioselectivity.