1282522-76-2Relevant academic research and scientific papers
Synthesis and antimicrobial activity of linked heterocyclics containing pyrazole-pyrimidine rings
Sanjeeva Reddy,Vani Devia,Rajesh Kumara,Sanjeeva Raoa,Nagarajb
experimental part, p. 1181 - 1186 (2011/10/12)
New series of 4-(aryl/hetaryl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2- pyrimidinamine 5a-j has been prepared and confirmed by IR, NMR, MS and elemental analyses. All the synthesized compounds have been tested for their antimicrobial activity against bacteria and fungi. Among the synthesized compounds, the compounds containing 4-nitrophenyl 5c, 2-furyl 5h and 2-thiazolyl 5j at 6-position of pyrimidine ring are highly active against all the organisms employed.
Synthesis and antimicrobial study of linked heterocyclics containing pyrazole-pyrimidine-thiazolidin-4-one
Sanjeeva Reddy, Cherkupally,Vani Devi, Macherla,Sunitha, Malladi,Nagaraj, Adki
experimental part, p. 1622 - 1626 (2011/02/22)
A new series of linked heterocyclics, 3-[4-(4-chlorophenyl)-6-(3,5- dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinyl]-2-(aryl/heteryl)-1, 3-thiazolan-4-ones (6a - j), has been synthesized by the one-pot cyclo-condensation of 4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4- pyrazolyl)-2-pyrimidinamine (5), aryl/heteroaryl aldehyde and thioglycolic acid. The structures of the synthesized compounds have been confirmed via IR, 1H-NMR, 13C-NMR, MS and elemental analyses. Further, all the newly synthesized compounds 6a - j have been assayed for their antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi. The compounds containing moieties like 4-nitrophenyl (6c), 3-nitrophenyl (6d), 4-dimethylaminophenyl (6g), 2-furyl (6i) and 1,3-benzodioxole (6j), at 2-position of thiazolidin-4-one ring exhibited good inhibitory activity against all the tested organisms.
