1282522-84-2Relevant academic research and scientific papers
Synthesis and antimicrobial study of linked heterocyclics containing pyrazole-pyrimidine-thiazolidin-4-one
Sanjeeva Reddy, Cherkupally,Vani Devi, Macherla,Sunitha, Malladi,Nagaraj, Adki
experimental part, p. 1622 - 1626 (2011/02/22)
A new series of linked heterocyclics, 3-[4-(4-chlorophenyl)-6-(3,5- dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinyl]-2-(aryl/heteryl)-1, 3-thiazolan-4-ones (6a - j), has been synthesized by the one-pot cyclo-condensation of 4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4- pyrazolyl)-2-pyrimidinamine (5), aryl/heteroaryl aldehyde and thioglycolic acid. The structures of the synthesized compounds have been confirmed via IR, 1H-NMR, 13C-NMR, MS and elemental analyses. Further, all the newly synthesized compounds 6a - j have been assayed for their antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi. The compounds containing moieties like 4-nitrophenyl (6c), 3-nitrophenyl (6d), 4-dimethylaminophenyl (6g), 2-furyl (6i) and 1,3-benzodioxole (6j), at 2-position of thiazolidin-4-one ring exhibited good inhibitory activity against all the tested organisms.
