1282523-80-1

Basic information

• Product Name: N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene
• Synonyms: N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene
• CAS NO: 1282523-80-1
• Molecular Weight: 322.404
• Mol File: 1282523-80-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene(1282523-80-1)
• EPA Substance Registry System: N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene(1282523-80-1)

Safety Data

• Hazardous Substances Data: 1282523-80-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 496-72-0 4-methyl-1,2-diaminobenzene 

Relevant articles and documents

Guanidine hydrochloride as an organocatalyst for N-Boc protection of amino groups

A simple and efficient method for the chemoselective N-Boc protection of the amine moiety in a variety of compounds is described using di-tert-butyl dicarbonate and guanidine hydrochloride as an organocatalyst in ethanol at 35-40°C. Selective mono-N-Boc protection of diamines and chemoselective protection of hydroxylamines without formation of any side products is achieved. Amino acids and peptides are N-Boc protected efficiently in excellent yields under convenient reaction conditions.

{[[K.18-Crown-6]Br3}n: A tribromide catalyst for the catalytic protection of amines and alcohols

{[K.18-Crown-6]Br3}n, a unique tribromide-type catalyst, was utilized for the N-boc protection of amines and trimethylsilylation (TMS) and tetrahydropyranylation (THP) of alcohols. The method is general for the preparation of N-boc derivatives of aliphatic (acyclic and cyclic) and aromatic, and primary and secondary amines and also various TMS-ethers and THP-ethers. The simple separation of the catalyst from the product is one of the many advantages of this method.