128253-55-4

Upstream product

• 13143-43-6 1-(4-phenylmethyl)-3-(4-methylphenyl)urea 
• 128253-50-9 3-benzyl-1-(4-tolyl)-1-nitrosourea 
• 100-46-9 benzylamine 
• 622-58-2 p-Tolylisocyanate 

Downstream Products

• 128253-57-6 3-benzyl-1-(2-nitro-4-tolyl)-3-nitrosourea 

Relevant academic research and scientific papers

Preparation method of O-nitroaryl urea compound

The invention discloses a preparation method of an o-nitryl aryl urea compound, and the method comprises the following steps: adding carbodiimide as shown in a formula I and ceric ammonium nitrate as shown in a formula II into an organic solvent for reaction, and performing separating and purifying after the reaction is completed to obtain the o-nitryl aryl urea compound as shown in a formula III, wherein R1 is selected from alkyl, alkoxy, trifluoromethyl, halogen or ester group; R2 is selected from alkyl, alkenyl or alkynyl. Carbodiimide and ceric ammonium nitrate are used as basic raw materials, and different substituted urea nitro compounds are obtained in one step. The reaction raw materials are easy to prepare, and the atom economy is high; reaction conditions are mild, and operability is high; and the substrate universality is high.