128256-20-2

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 71316-14-8 N'-(4-methylphenyl)-N-(triphenylphosphoranylidene)-benzenecarboximidamide 
• 66275-61-4 N-Chloro-N'-(4-methylphenyl)benzamidine 

Relevant academic research and scientific papers

Quinazolines by electrocyclic ring closure of 1,3-diaza-1,3-dienes

N-imidoyliminotripheny]phosphorane reacts with aliphatic and aromatic aldehydes to give via an 1,3-diaza-1,3-diene intermediate 3,4-dihydro quinazolines and quinazolines. The ratio between the reaction products depends from the aldehyde employed.

A convenient synthesis of Quinazoline ring by tandem aza-Wittig reaction/electrocyclic ring closure

3,4-D-Dihydroquinazolines and Quinazolines were prepared starting from N'-aryl-N-(triphenylphosphoranilidene)-carboximidamides and aliphatic or aromatic aldehydes. The mechanism of the reaction is discussed.