128259-76-7Relevant academic research and scientific papers
Novel process for the synthesis of 2-fluoro-1-olefins
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, (2008/06/13)
A process for preparing 2-fluoro-1-olefins or terminal bis-beta-fluoro-olefins which comprises reacting an appropriate allyl or alpha-olefinated starting material with phenylselenyl chloride and silver fluoride, and then reacting the intermediate phenylselenyl fluoride compound with ozone, and further reacting the resulting phenylselenoxide compound with an appropriate amine, to yield the desired fluorinated compounds.
PHARMACEUTICALLY ACTIVE 3-HETEROARYL-2-FLUORO-1-OLEFINS
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, (2008/06/13)
This invention relates to novel 3-heteroaryl-2-fluoro-l-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.
A new synthesis of 2-fluoro-1-olefins
McCarthy, James R.,Matthews, Donald P.,Barney, Charlotte L.
, p. 973 - 976 (2007/10/02)
The first examples of the addition of PhSeF to olefins to yield β-fluoro phenylselenides (2) are reported. β-Fluoro phenylselenides (2) obtained from terminal olefins were converted to the title vinyl fluorides 3 on treatment with ozone, whereas, 2 obtain
