128260-40-2

Upstream product

• 49670-40-8 2-methanesulfonyloxybenzaldehyde 
• 127-91-3 (1S)-(-)-β-pinene 

Downstream Products

• 128260-39-9 2-[6,6-Dimethyl-bicyclo[3.1.1]hept-(2E)-ylidene]-1-(2-hydroxy-phenyl)-ethanone 
• 128260-41-3 Methanesulfonic acid 2-[2-(6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-yl)-acetyl]-phenyl ester 

Relevant academic research and scientific papers

Stereoselective construction of the ring system of Robustadials

The spiro[3,4-dihydro-2H-1-benzopyran-2,2'-bicyclo[3.1.1]heptane] framework of natural products Robustadials was constructed in a homochiral form. The synthesis started from 1S-(-)-β-pinene, which was coupled to a substituted benzaldehyde using a Prins reaction, and incorporated a diastereoselective, Michael-type, intramolecular addition.