128272-35-5Relevant academic research and scientific papers
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Akwabi-Ameyaw, Adwoa,Bass, Jonathan Y.,Caldwell, Richard D.,Caravella, Justin A.,Chen, Lihong,Creech, Katrina L.,Deaton, David N.,Jones, Stacey A.,Kaldor, Istvan,Liu, Yaping,Madauss, Kevin P.,Marr, Harry B.,McFadyen, Robert B.,Miller, Aaron B.,III, Frank Navas,Parks, Derek J.,Spearing, Paul K.,Todd, Dan,Williams, Shawn P.,Wisely, G. Bruce
supporting information; experimental part, p. 4339 - 4343 (2009/04/06)
Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severit
FARNESOID X RECEPTOR AGONISTS
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Page/Page column 57, (2010/11/27)
The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
