128278-08-0Relevant academic research and scientific papers
AMINODEMETHOXYLATION IN QUINOLINES AND NAPHTHALENES
Terenin, V. I.,Gerasimenko, V. A.,Nikishova, N. G.,Kurts, A. L.,Afanas'eva, T. A.,Bundel', Yu. G.
, p. 1890 - 1896 (2007/10/02)
Substitution of the methoxy group in inactivated aromatic and heterocyclic substrates by alkylamines takes place by bimolecular nucleophilic substitution at a saturated carbon atom with the formation of phenolic intermediates and subsequent substitution of the hydroxyl group by the alkylamino group.In the temperature range between 150 and 200 deg C in the presence of ammonium chloride the substitution of the hydroxy group in 1- and 2-hydroxynaphthalenes and 6-, 7-, and 8-hydroxyquinolines, and of the methoxy group in 1- and 2-methoxynaphthalenes and 6-, 7-, and 8-methoxyquinolines takes place almost quantitatively.
