128291-67-8Relevant academic research and scientific papers
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction
Yin, Hang,Lee, Gui-In,Hyung, Soon Park,Payne, Gregory A.,Rodriguez, Johanna M.,Sebti, Said M.,Hamilton, Andrew D.
, p. 2704 - 2707 (2007/10/03)
(Chemical Equation Presented) HDM2 regulates p53 by binding to its transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic analysis of the HDM2/p53 complex revealed that three hydrophobic residues (F19, W23, L26) along one face of the p53 helical peptide are essential for binding (see picture). Terphenyl-based antagonists mimic the α-helical region of p53 and disrupt HDM2/p53 complexation.
Synthesis of (+/-)-Pisiferin, (+/-)-Pisiferol, and Related Compounds by Intramolecular Cycloaddition
Kametani, Tetsuji,Kondoh, Hirotsune,Tsubuki, Masayoshi,Honda, Toshio
, p. 5 - 10 (2007/10/02)
Thermolysis of the olefinic benzocyclobutene (17) afforded the tricyclic compounds (18a) and (18b), whose sequential reduction, via the aldehyde (19), gave rise to the pisiferol derivatives (20a) and (20b).Since (20a) was transformed into pisiferol (2), p
