128293-12-9

Upstream product

• 128292-91-1 Methyl (E)-2-Formylmethyl-2-phenylsulfonyl-4-(2,6,6-trimethylcyclohex-1-enyl)but-3-enoate 
• 223419-01-0 methyl (E,E)-4-hydroxy-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>but-2-enoate 
• 101315-21-3 (E)-5-(2,6,6-trimethylcyclohex-1-enyl)pent-4-en-2-yn-1-ol 
• 73395-75-2 (E)-2-(but-1-en-3-ynyl)-1,3,3-trimethylcyclohex-1-ene 
• 204063-23-0 (E,E)-4-hydroxy-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>but-2-enoic acid 
• 79-77-6 (E)-β-ionone 
• 14393-44-3 (E)-3-(2,6,6-trimethylcyclohex-1-en-1-yl)prop-2-en-1-ol 
• 115580-80-8 (E)-<3-(2,6,6-Trimethylcyclohex-1-enyl)allyl>sulfonylbenzene 
• 115580-82-0 Methyl (E)-2-Phenylsulfonyl-4-(2,6,6-trimethylcyclohex-1-enyl)but-3-enoate 
• 115580-84-2 Methyl (E)-2-Phenylsulfonyl-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>pent-4-enoate 

Downstream Products

• 128292-90-0 methyl (Z,E)-4-oxo-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>but-2-enoate 
• 344908-14-1 methyl (E,E)-5-aza-N-hydroxy-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl]-2,4-pentadienoate 
• 461640-94-8 4-(2,6,6-trimethyl-cyclohex-1-enyl)-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid methyl ester 
• 115650-12-9 5-[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraen-(E)-ylidene]-3-[(E)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-vinyl]-5H-furan-2-one 
• 461641-18-9 (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-(2,6,6-trimethylcyclohex-1-enyl)-1,2,5,6-tetrahydropyridin-1-yl]-indan-2-ol 

Relevant academic research and scientific papers

The inhibitory mechanism of bovine pancreatic phospholipase A2 by aldehyde terpenoids

We established the stereoselective synthesis of (E)-3-methoxycarbonyl- 2,4,6-trienal compound A and discovered that the compound A showed more powerful inhibitory activity toward phospholipase A2(PLA2) from bovine pancreas than manoalide which is a typical PLA2 inhibitor. As the inhibitory mechanism of PLA2 by A, the irreversible formation of dihydropyridine derivative resulting from the reaction of A with lysine residues in PLA2 was proposed based on the model reactions. Furthermore, A was found to selectively modify Lys56 which is included in the interfacial recognition site of this enzyme by the MALDI-TOF-MS peptide mapping analyses.

Synthesis of a new phospholipase A2 inhibitor of an aldehyde terpenoid and its possible inhibitory mechanism

3-(E)Methoxycarbonyl-2,4,6-trienal compound A was stereoselectively synthesized and found to show strong inhibitory activity toward phospholipase A2 (PLA2) from bovine pancreas. As the inhibitory mechanism of PLA2 by A, the irreversible formation of dihydropyridine resulting from the reaction of A with lysine residues in PLA2 is proposed based on the model reactions.

Retinoids and Related Compounds. Part 14. A Novel Synthesis of Conjugated 4-Alkylidenebutenolides and Their Spectral Characterization

A novel synthesis (the sulfone method) of carotenoidal alkylidenebutenolides is described together with spectral characterization of the latter.

Synthesis of the 4-Alkylidenebutenolide Carotenoids, Peridinin and Pyrrhoxanthin

A novel synthetic method of carotenoidal alkylidenebutenolides has been developed, and applied to the first synthesis of peridinin (1) and pyrrhoxanthin (2).